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KMID : 0438219740110021159
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Korea University Medical Journal
1974 Volume.11 No. 2 p.1159 ~ p.1171
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Effect of Formaldehyde Gas Inhalation on the Tracheo-Bronchial Tree of the Rabbit
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Abstract
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Experimental tracheo-bronchial injuries were histologically reappraised by means of repeated inhalation of formaldehyde gas in the rabbits, and their chronological sequences of reparative process were analized.
Animals used for the experiment were 34 healthy adult rabbits weighing approximately 1.5kg, all being free of broncho-pulmonary disorders. Formaldehyde gas was administered according to Holland method and representative sections from the definite sites of larynx and tracheo bronchial tree were processed histologically. The results and summary are as follows:
1. All the animals exposed to the repeated formaldehyde gas inhalation demonstrated rather diffuse inflammatory and degenerative alterations accompanied by epithelial regeneration and complicated reparative changes during the course.
2. In the early phase (1-10 days) of the experiment, a certain serial changes, i.e. destruction and desquamation of epithelium, submucosal necrosis and hemorrhages, and advanced acute necrotizing inflammation to form pseudemembranous tracheobronchitis, were demonstrated.
3. The lesions observed in the mid phase (11-30 days) were characterized by various changes ranging simply from denudation of necrotizing epithelium to newly regenerating cells as well as inflammatory repair which included new granulation tissue formation in the submucosa.
4. During the late phase(31-60 days) of the experiment changes were modified by those featuring gradational alterations of epithelial regeneration and inflammatory repairs with persistent but much mild inflammatory cell infiltrates.
The above findings following repeated inhalation of formaldehyde gas indicate that necrotizing and hemorrhagic pseudomembraneous tracheobronchitis of early phase becomes modified by features of epithelial regeneration during the course of mid phase, and of advanced inflammatory repairs directing dense and mature granulation tissue and squamous cell epithelium in the late phase.
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